Publications Durham NC | HIV Publications & Articles

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Breaking through Immunity's Glass Ceiling.

G. Kelsoe, B. F. Haynes, Cold Spring Harb Perspect Biol, (2017); published online EpubJun 19 (10.1101/cshperspect.a029397).

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

T. Bradley, J. Pollara, S. Santra, N. Vandergrift, S. Pittala, C. Bailey-Kellogg, X. Shen, R. Parks, D. Goodman, A. Eaton, H. Balachandran, L. V. Mach, K. O. Saunders, J. A. Weiner, R. Scearce, L. L. Sutherland, S. Phogat, J. Tartaglia, S. G. Reed, S. L. Hu, J. F. Theis, A. Pinter, D. C. Montefiori, T. B. Kepler, K. K. Peachman, M. Rao, N. L. Michael, T. J. Suscovich, G. Alter, M. E. Ackerman, M. A. Moody, H. X. Liao, G. Tomaras, G. Ferrari, B. T. Korber, B. F. Haynes, Nat Commun 8, 15711 (2017); published online EpubJun 8 (10.1038/ncomms15711).

Unusual antigen presentation offers new insight into HIV vaccine design

A. J. McMichael, L. J. Picker, Curr Opin Immunol 46, 75-81 (2017); published online EpubJun (10.1016/j.coi.2017.04.009).

An entry-competent intermediate state of the HIV-1 envelope glycoproteins

A. Herschhorn, J. Sodroski, Receptors & clinical investigation 4, (2017); published online (10.14800/rci.1544).

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Zhou T, Doria-Rose N.A., Cheng C, Stewart-Jones G.B.E, Chuang G.Y., Chambers M, Druz A, Geng H, McKee K, Kwon Y.D., O'Dell S, Sastry M, Schmidt S.D., Xu K, Chen L, Chen R.E., Louder M.K., Pancera M, Wanninger T.G., Zhang B, Zheng A, Farney S.K., Foulds K.E., Georgiev I.S., Joyce M.G., Lemmin T, Narpala S, Rawi R, Soto C, Todd J.P., Shen C.H., Tsybovsky Y, Yang Y, Zhao P, Haynes B.F., Stamatatos L, Tiemeyer M, Wells L, Scorpio D.G., Shapiro L, McDermott A.B., Mascola J.R., Kwong P.D. Cell Rep. 2017 Apr 25;19(4):719-732. doi: 10.1016/j.celrep.2017.04.013.vPMID: 28445724

HIV-1 consensus envelope-induced broadly binding antibodies.

Meyerhoff R.R., Scearce R.M., Ogburn D.F., Lockwood B, Pickeral J, Kuraoka M, Anasti K, Eudailey J, Eaton A, Cooper M, Wiehe K, Montefiori D.C., Tomaras G.D., Ferrari G, Alam S.M., Liao H.X., Korber B, Gao F, Haynes B.FAIDS Res Hum Retroviruses. 2017 Mar 17. doi: 10.1089/AID.2016.0294. [Epub ahead of print] PMID: 28314374

Developing an HIV vaccine.

694. Haynes B.F., Burton D.R. Science. 2017 Mar 17;355(6330):1129-1130. doi: 10.1126/science.aan0662. Epub 2017 Mar 16. No abstract available. PMID: 28302812

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Bonsignori M, Kreider E.F., Fera D, Meyerhoff R.R., Bradley T, Wiehe K, Alam S.M., Aussedat B., Walkowicz W.E., Hwang K.K., Saunders K.O., Zhang R, Gladden M.A., Monroe A, Kumar A, Xia S.M., Cooper M, Louder M.K., McKee K, Bailer R.T., Pier B.W., Jette C.A., Kelsoe G, Williams W.B., Morris L, Kappes J, Wagh K, Kamanga G, Cohen M.S., Hraber P.T., Montefiori D.C., Trama A, Liao H.X., Kepler T.B., Moody M.A., Gao F, Danishefsky S.J., Mascola J.R., Shaw G.M., Hahn B.H., Harrison S.C., Korber B.T., Haynes B.F. Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7514. doi: 10.1126/scitranslmed.aai7514. PMID: 28298420

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

Alam S.M., Aussedat B, Vohra Y, Ryan Meyerhoff R, Cale E.M., Walkowicz W.E., Radakovich N.A., Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce M.G., Pancera M, Druz A, Georgiev I.S., Von Holle T, Eaton A, Fox C, Reed S.G., Louder M, Bailer R.T., Morris L, Abdool-Karim S.S., Cohen M, Liao H.X., Montefiori D.C., Park P.K., Fernández-Tejada A, Wiehe K, Santra S, Kepler T.B., Saunders K.O., Sodroski J, Kwong P.D., Mascola J.R., Bonsignori M, Moody M.A., Danishefsky S, Haynes B.F. Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7521. doi: 10.1126/scitranslmed.aai7521. PMID: 28298421

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.

Saunders KO, Nicely NI, Wiehe K, Bonsignori M, Meyerhoff RR, Parks R, Walkowicz WE, Aussedat B, Wu NR, Cai F, Vohra Y, Park PK, Eaton A, Go EP, Sutherland LL, Scearce RM, Barouch DH, Zhang R, Von Holle T, Overman RG, Anasti K, Sanders RW, Moody MA, Kepler TB, Korber B, Desaire H, Santra S, Letvin NL, Nabel GJ, Montefiori DC, Tomaras GD, Liao HX, Alam SM, Danishefsky SJ, Haynes BF.

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