2013-2006 Publications

2013 Publications

Tomaras GD, Ferrari G, Shen X, Alam SM, Liao HX, Pollara J, Bonsignori M, Moody MA, Fong Y, Chen X, Poling B, Nicholson CO, Zhang R, Lu X, Parks R, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Gilbert PB, Kim JH, Michael NL, Montefiori DC, Haynes BF. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proc Natl Acad Sci U S A. 2013 May 9. [Epub ahead of print] Abstract

Liu P, Yates NL, Shen X, Bonsignori M, Moody MA, Liao HX, Fong Y, Alam SM, Overman RG, Denny T, Ferrari G, Ochsenbauer C, Kappes JC, Polonis V, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Montefiori DC, Gilbert P, Michael NL, Kim JH, Haynes BF, Tomaras GD. Infectious Virion Capture by HIV-1 gp120 Specific IgG from RV144 Vaccinees. J Virol. 2013 May 8. [Epub ahead of print] Abstract

Ping LH, Joseph SB, Anderson JA, Abrahams MR, Salazar-Gonzalez JF, Kincer LP, Treurnicht FK, Arney L, Ojeda S, Zhang M, Keys J, Potter EL, Chu H, Moore P, Salazar-Gonzalez M, Iyer S, Jabara C, Kirchherr J, Mapanje C, Ngandu N, Seoighe C, Hoffman I, Gao F, Tang Y, Labranche C, Lee B, Saville A, Vermeulen M, Fiscus S, Morris L, Abdool Karim S, Haynes BF, Shaw GM, Korber BT, Hahn BH, Cohen MS, Montefiori D, Williamson C, Swanstrom R; for the CAPRISA Acute Infection Study the Center for HIV-AIDS Vaccine Immunology Consortium. Comparison of Viral Env Proteins From Acute and Chronic Infections of Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences In Glycosylation and CCR5 Utilization and Suggests A New Strategy For Immunogen Design. J Virol. 2013 Apr 24. [Epub ahead of print] Abstract

Fouda GG, Amos JD, Wilks AB, Pollara J, Ray CA, Chand A, Kunz EL, Liebl BE, Whitaker K, Carville A, Smith S, Colvin L, Pickup DJ, Staats HF, Overman G, Eutsey-Lloyd K, Parks R, Chen H, Labranche C, Barnett S, Tomaras GD, Ferrari G, Montefiori DC, Liao HX, Letvin NL, Haynes BF, Permar SR. Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 Envelope induces strong Env-specific IgA antibody responses in breast milk. J Virol. 2013 Apr 17. [Epub ahead of print] Abstract

Liao HX, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L; NISC Comparative Sequencing Program, Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia SM, Montefiori DC, Parks R, Lloyd KE, Scearce RM, Soderberg KA, Cohen M, Kamanga G, Louder MK, Tran LM, Chen Y, Cai F, Chen S, Moquin S, Du X, Joyce MG, Srivatsan S, Zhang B, Zheng A, Shaw GM, Hahn BH, Kepler TB, Korber BT, Kwong PD, Mascola JR,Haynes BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013 Apr 25; 496(7446): 469-76. Abstract

Parrish NF, Gao F, Li H, Giorgi EE, Barbian HJ, Parrish EH, Zajic L, Iyer SS, Decker JM, Kumar A, Hora B, Berg A, Cai F, Hopper J, Denny TN, Ding H, Ochsenbauer C, Kappes JC, Galimidi RP, West AP Jr, Bjorkman PJ, Wilen CB, Doms RW, O'Brien M, Bhardwaj N, Borrow P, Haynes BF, Muldoon M, Theiler JP, Korber B, Shaw GM, Hahn BH. Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17): 6626-33. Abstract

Lane J, McLaren PJ, Dorrell L, Shianna KV, Stemke A, Pelak K, Moore S, Oldenburg J, Alvarez-Roman MT, Angelillo-Scherrer A, Boehlen F, Bolton-Maggs PH, Brand B, Brown D, Chiang E, Cid-Haro AR, Clotet B, Collins P, Colombo S, Dalmau J, Fogarty P, Giangrande P, Gringeri A, Iyer R, Katsarou O, Kempton C, Kuriakose P, Lin J, Makris M, Manco-Johnson M, Tsakiris DA, Martinez-Picado J, Mauser-Bunschoten E, Neff A, Oka S, Oyesiku L, Parra R, Peter-Salonen K, Powell J, Recht M, Shapiro A, Stine K, Talks K, Telenti A, Wilde J, Yee TT, Wolinsky SM, Martinson J, Hussain SK, Bream JH, Jacobson LP, Carrington M, Goedert JJ, Haynes BF, McMichael AJ, Goldstein DB, Fellay J; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Hum Mol Genet. 2013 May 1; 22(9): 1903-10. Abstract

Liao HX, Tsao CY, Alam SM, Muldoon M, Vandergrift N, Ma BJ, Lu X, Sutherland LL, Scearce RM, Bowman C, Parks R, Chen H, Blinn JH, Lapedes A, Watson S, Xia SM, Foulger A, Hahn BH, Shaw GM, Swanstrom R, Montefiori DC, Gao F, Haynes BF, Korber B. Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1. J Virol. 2013 Apr; 87(8): 4185-201. Abstract

Yang G, Holl TM, Liu Y, Li Y, Lu X, Nicely NI, Kepler TB, Alam SM, Liao HX, Cain DW, Spicer L, VandeBerg JL, Haynes BF, Kelsoe G. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med. 2013 Feb 11; 210(2): 241-56. Abstract

Zolla-Pazner S, deCamp AC, Cardozo T, Karasavvas N, Gottardo R, Williams C, Morris DE, Tomaras G, Rao M, Billings E, Berman P, Shen X, Andrews C, O'Connell RJ, Ngauy V, Nitayaphan S, de Souza M, Korber B, Koup R, Bailer RT, Mascola JR, Pinter A, Montefiori D, Haynes BF, Robb ML, Rerks-Ngarm S, Michael NL, Gilbert PB, Kim JH. Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial. PLoS One. 2013; 8(1): e53629. Abstract

Go EP, Liao HX, Alam SM, Hua D, Haynes BF, Desaire H. Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins. J Proteome Res. 2013 Mar 1;12(3):1223-34. Abstract

Liao HX, Bonsignori M, Alam SM, McLellan JS, Tomaras GD, Moody MA, Kozink DM, Hwang KK, Chen X, Tsao CY, Liu P, Lu X, Parks RJ, Montefiori DC, Ferrari G, Pollara J, Rao M, Peachman KK, Santra S, Letvin NL, Karasavvas N, Yang ZY, Dai K, Pancera M, Gorman J, Wiehe K, Nicely NI, Rerks-Ngarm S, Nitayaphan S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Sinangil F, Kim JH, Michael NL, Kepler TB, Kwong PD, Mascola JR, Nabel GJ, Pinter A, Zolla-Pazner S, Haynes BF. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 2013 Jan 24; 38(1): 176-86. Abstract

Yates NL, Stacey AR, Nolen TL, Vandergrift NA, Moody MA, Montefiori DC, Weinhold KJ, Blattner WA, Borrow P, Shattock R, Cohen MS, Haynes BF, Tomaras GD. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal Immunol. 2013 Jan 9. Abstract

Alam SM, Liao HX, Tomaras GD, Bonsignori M, Tsao CY, Hwang KK, Chen H, Lloyd KE, Bowman C, Sutherland L, Jeffries TL Jr, Kozink DM, Stewart S, Anasti K, Jaeger FH, Parks R, Yates NL, Overman RG, Sinangil F, Berman PW, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Karasavva N, Rerks-Ngarm S, Kim JH, Michael NL, Zolla-Pazner S, Santra S, Letvin NL, Harrison SC, Haynes BF. Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. J Virol. 2013 Feb; 87(3): 1554-68. Abstract

2012 Publications

Frleta D, Ochoa CE, Kramer HB, Khan SA, Stacey AR, Borrow P, Kessler BM, Haynes BF, Bhardwaj N. HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. J Clin Invest. 2012 Dec 3; 122(12): 4685-97. Abstract

Baalwa J, Wang S, Parrish NF, Decker JM, Keele BF, Learn GH, Yue L, Ruzagira E, Ssemwanga D, Kamali A, Amornkul PN, Price MA, Kappes JC, Karita E, Kaleebu P, Sanders E, Gilmour J, Allen S, Hunter E, Montefiori DC, Haynes BF, Cormier E, Hahn BH, Shaw GM. Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones. Virology. 2013 Feb 5;436(1):33-48. Abstract

Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM, Goonetilleke N, Liu MK, Berg A, Hora B, Drinker MS, Eudailey J, Pickeral J, Moody MA, Ferrari G, McMichael A, Perelson AS, Shaw GM, Hahn BH, Haynes BF, Gao F. Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome. Retrovirology. 2012 Oct 30; 9:89. Abstract

Karasavvas N, Billings E, Rao M, Williams C, Zolla-Pazner S, Bailer RT, Koup RA, Madnote S, Arworn D, Shen X, Tomaras GD, Currier JR, Jiang M, Magaret C, Andrews C, Gottardo R, Gilbert P, Cardozo TJ, Rerks-Ngarm S, Nitayaphan S, Pitisuttithum P, Kaewkungwal J, Paris R, Greene K, Gao H, Gurunathan S, Tartaglia J, Sinangil F, Korber BT, Montefiori DC, Mascola JR, Robb ML, Haynes BF, Ngauy V, Michael NL, Kim JH, de Souza For The Moph Taveg Collaboration MS. The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120. AIDS Res Hum Retroviruses. 2012 Oct 4. [Epub ahead of print] Abstract

Haynes BF, Permar S. A tribute to Norman L. Letvin (1949–2012). J Clin Invest. 2012 Aug 1; 122(8): 2709-10. No abstract available.

Bonsignori M, Alam SM, Liao HX, Verkoczy L, Tomaras GD, Haynes BF, Moody MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends Microbiol. 2012 Sep 13. pii: S0966-842X(12)00156-4. Abstract

Li H, Stoddard MB, Wang S, Blair LM, Giorgi EE, Parrish EH, Learn GH, Hraber P, Goepfert PA, Saag MS, Denny TN, Haynes BF, Hahn BH, Ribeiro RM, Perelson AS, Korber BT, Bhattacharya T, Shaw GM. Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing. PLoS Pathog. 2012 Aug; 8(8): e1002880. Abstract

Bonsignori M, Pollara J, Moody MA, Alpert MD, Chen X, Hwang KK, Gilbert PB, Huang Y, Gurley TC, Kozink DM, Marshall DJ, Whitesides JF, Tsao CY, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Kim JH, Michael NL, Tomaras GD, Montefiori DC, Lewis GK, Devico A, Evans DT, Ferrari G, Liao HX, Haynes BF. Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family. J Virol. 2012 Nov; 86(21): 11521-32. Abstract

Nabel GJ, Wolinsky SM, Haynes BF. Retrospective. Norman L. Letvin (1949-2012). Science. 2012 Jun 29;336(6089):1653. No abstract available.

Chang HH, Soderberg K, Skinner JA, Banchereau J, Chaussabel D, Haynes BF, Ramoni M, Letvin NL. Transcriptional network predicts viral set point during acute HIV-1 infection. J Am Med Inform Assoc. 2012 Nov 1;19(6):1103-9. doi: 10.1136/amiajnl-2012-000867. Abstract

Bar KJ, Tsao CY, Iyer SS, Decker JM, Yang Y, Bonsignori M, Chen X, Hwang KK, Montefiori DC, Liao HX, Hraber P, Fischer W, Li H, Wang S, Sterrett S, Keele BF, Ganusov VV, Perelson AS, Korber BT, Georgiev I, McLellan JS, Pavlicek JW, Gao F, Haynes BF, Hahn BH, Kwong PD, Shaw GM. Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. PLoS Pathog. 2012; 8(5): e1002721. Abstract

Parrish NF, Wilen CB, Banks LB, Iyer SS, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Hora B, Kumar A, Mahlokozera T, Yuan S, Coleman C, Vermeulen M, Ding H, Ochsenbauer C, Tilton JC, Permar SR, Kappes JC, Betts MR, Busch MP, Gao F, Montefiori D, Haynes BF, Shaw GM, Hahn BH, Doms RW. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7. PLoS Pathog. 2012; 8(5): e1002686. Abstract

Montefiori DC, Karnasuta C, Huang Y, Ahmed H, Gilbert P, de Souza MS, McLinden R, Tovanabutra S, Laurence-Chenine A, Sanders-Buell E, Moody MA, Bonsignori M, Ochsenbauer C, Kappes J, Tang H, Greene K, Gao H, LaBranche CC, Andrews C, Polonis VR, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Self SG, Berman PW, Francis D, Sinangil F, Lee C, Tartaglia J, Robb ML, Haynes BF, Michael NL, Kim JH. Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials. J Infect Dis. 2012 Aug 1; 206(3): 431-41. Abstract

Doria-Rose NA, Georgiev I, O'Dell S, Chuang GY, Staupe RP, McLellan JS, Gorman J, Pancera M, Bonsignori M, Haynes BF, Burton DR, Koff WC, Kwong PD, Mascola JR. A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol. 2012 Aug; 86(15): 8319-23. Abstract

Yaming Wang, Melissa Swiecki, Marina Cella, Gottfried Alber, Robert D. Schreiber, Susan Gilfillan, Marco Colonna, Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection, Cell Host & Microbe, Volume 11, Issue 6, 14 June 2012, Pages 631-642.Abstract

Nancie M. Archin, Naveen K. Vaidya, JoAnn D. Kuruc, Abigail L. Liberty, Ann Wiegand, Mary F. Kearney, Myron S. Cohen, John M. Coffin, Ronald J. Bosch, Cynthia L. Gay, Joseph J. Eron, David M. Margolis, and Alan S. Perelson. Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection. PNAS. 2012 ; published ahead of print May 29, 2012. Abstract

Friedman J, Alam SM, Shen X, Xia S-M, Stewart S, et al. Isolation of HIV-1-Neutralizing Mucosal Monoclonal Antibodies from Human Colostrum. PLoS One. 7(5): e37648. Full Text

Lynch RM, Tran L, Louder MK, Schmidt SD, Cohen M; the CHAVI 001 clinical team, Dersimonian R, Euler Z, Gray ES, Abdool Karim S, Kirchherr J, Montefiori DC, Sibeko S, Soderberg K, Tomaras G, Yang ZY, Nabel GJ, Schuitemaker H, Morris L, Haynes BF, Mascola JR. The Development of CD4 Binding Site Antibodies During HIV-1 Infection. J Virol. 2012 May 9. [Epub ahead of print] Abstract

Haynes BF, Kelsoe G, Harrison SC, Kepler TB. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol. 2012 May 7; 30(5): 423-33. Abstract

Moody MA, Yates NL, Amos JD, Drinker MS, Eudailey JA, Gurley TC, Marshall DJ, Whitesides JF, Chen X, Foulger A, Yu JS, Zhang R, Meyerhoff RR, Parks R, Scull JC, Wang L, Vandergrift NA, Pickeral J, Pollara J, Kelsoe G, Alam SM, Ferrari G, Montefiori DC, Voss G, Liao HX, Tomaras GD, Haynes BF. HIV-1 gp120 Vaccine Induces Affinity Maturation in Both New and Persistent Antibody Clonal Lineages. J Virol. 2012 May 2. [Epub ahead of print] Abstract

Freel SA, Picking RA, Ferrari G, Ding H, Ochsenbauer C, Kappes JC, Kirchherr J, Soderberg K, Weinhold KJ, Cunningham CK, Denny T, Crump JA, Cohen MS, McMichael AJ, Haynes BF, Tomaras GD. Initial HIV- 1 Antigen-specific CD8+ T cells In Acute HIV-1 Inhibit Transmitted Founder Virus Replication. J Virol. 2012 Apr 18. [Epub ahead of print] Abstract

McMichael AJ, Haynes BF. Lessons learned from HIV-1 vaccine trials: new priorities and directions. Nat Immunol. 2012 Apr 18; 13(5): 423-7. Abstract

Hardy GJ, Lam Y, Stewart SM, Anasti K, Alam SM, Zauscher S. Screening the interactions between HIV-1 neutralizing antibodies and model lipid surfaces. J Immunol Methods. 2012 Feb 28; 376(1-2):13-9. Abstract

Haynes BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, DeVico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, DeCamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, de Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH. Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial. N Engl J Med 2012; 366:1275-1286. Abstract

Bonsignori M, Montefiori DC, Wu X, Chen X, Hwang KK, Tsao CY, Kozink DM, Parks RJ, Tomaras GD, Crump JA, Kapiga SH, Sam NE, Kwong PD, Kepler TB, Liao HX, Mascola JR, Haynes BF. Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-infected Donor: Implications for Vaccine Design. J Virol. 2012 Feb 1. [Epub ahead of print] Abstract

Riou C, Ganusov VV, Campion S, Mlotshwa M, Liu MK, Whale VE, Goonetilleke N, Borrow P, Ferrari G, Betts MR, Haynes BF, McMichael AJ, Gray CM. Distinct Kinetics of Gag-Specific CD4+ and CD8+ T Cell Responses during Acute HIV-1 Infection. J Immunol. 2012 Mar 1;188(5):2198-206. Epub 2012 Jan 27. Abstract

Ochsenbauer C, Edmonds TG, Ding H, Keele BF, Decker J, Salazar MG, Salazar-Gonzalez JF, Shattock R, Haynes BF, Shaw GM, Hahn BH, Kappes JC. Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages. J Virol. 2012 Mar;86(5):2715-28. Abstract

Hwang KK, Chen X, Kozink DM, Gustilo M, Marshall DJ, Whitesides JF, Liao HX, Catera R, Chu CC, Yan XJ, Luftig MA, Haynes BF, Chiorazzi N. Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. Blood. 2012 Feb 16;119(7):e35-44. Abstract

Lavine CL, Lao S, Montefiori DC, Haynes BF, Sodroski JG, Yang X; the NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human Immunodeficiency Virus Type 1 Infection. J Virol. 2012 Feb;86(4):2153-2164. Epub 2011 Dec 7. Abstract

2011 Publications

Ochsenbauer C, Edmonds TG, Ding H, Keele BF, Decker J, Salazar MG, Salazar-Gonzalez JF, Shattock R, Haynes BF, Shaw GM, Hahn BH, Kappes JC. Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of their Replication Capacity in CD4 T-Lymphocytes and Monocyte-derived Macrophages. J Virol. 2011 Dec 21. [Epub ahead of print] Abstract

Hwang KK, Chen X, Kozink DM, Gustilo M, Marshall DJ, Whitesides JF, Liao HX, Catera R, Chu CC, Yan XJ, Luftig MA, Haynes BF, Chiorazzi N. Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by co-culture with macrophage feeder cells. Blood. 2011 Dec 12. [Epub ahead of print] Abstract

Lavine CL, Lao S, Montefiori DC, Haynes BF, Sodroski JG, Yang X; the NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Infection of Human Immunodeficiency Virus Type 1. J Virol. 2011 Dec 7. [Epub ahead of print] Abstract

Dennison SM, Sutherland LL, Jaeger FH, Anasti KM, Parks R, Stewart S, Bowman C, Xia SM, Zhang R, Shen X, Scearce RM, Ofek G, Yang Y, Kwong PD, Santra S, Liao HX, Tomaras G, Letvin NL, Chen B, Alam SM, Haynes BF. Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41. PLoS One. 2011;6(11):e27824. Abstract

Pelak K, Need AC, Fellay J, Shianna KV, Feng S, Urban TJ, Ge D, De Luca A, Martinez-Picado J, Wolinsky SM, Martinson JJ, Jamieson BD, Bream JH, Martin MP, Borrow P, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Carrington M, Goldstein DB, Alter G; on behalf of NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). Copy Number Variation of KIR Genes Influences HIV-1 Control. PLoS Biol. 2011 Nov;9(11):e1001208. Abstract

McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011 Nov 23;480(7377):336-43. Abstract

Moody MA, Zhang R, Walter EB, Woods CW, Ginsburg GS, McClain MT, Denny TN, Chen X, Munshaw S, Marshall DJ, Whitesides JF, Drinker MS, Amos JD, Gurley TC, Eudailey JA, Foulger A, Derosa KR, Parks R, Meyerhoff RR, Yu JS, Kozink DM, Barefoot BE, Ramsburg EA, Khurana S, Golding H, Vandergrift NA, Alam SM, Tomaras GD, Kepler TB, Kelsoe G, Liao HX, Haynes BF. H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination. PLoS One. 2011. 6(10): e25797. Abstract

Bolton DL, Song K, Wilson RL, Kozlowski PA, Tomaras GD, Keele BF, Lovingood RV, Rao S, Roederer M. Comparison of systemic and mucosal vaccination: impact on intravenous and rectal SIV challenge. Mucosal Immunol. 2011 Oct 26. [Epub ahead of print] Abstract

Liao HX, Chen X, Munshaw S, Zhang R, Marshall DJ, Vandergrift N, Whitesides JF, Lu X, Yu JS, Hwang KK, Gao F, Markowitz M, Heath SL, Bar KJ, Goepfert PA, Montefiori DC, Shaw GC, Alam SM, Margolis DM, Denny TN, Boyd SD, Marshal E, Egholm M, Simen BB, Hanczaruk B, Fire AZ, Voss G, Kelsoe G, Tomaras GD, Moody MA, Kepler TB, Haynes BF. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med. 2011 Oct 10. [Epub ahead of print]Abstract

Morris L, Chen X, Alam M, Tomaras G, Zhang R, Marshall DJ, Chen B, Parks R, Foulger A, Jaeger F, Donathan M, Bilska M, Gray ES, Abdool Karim SS, Kepler TB, Whitesides J, Montefiori D, Moody MA, Liao HX, Haynes BF. Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B Cell Sorting. PLoS One. 2011;6(9):e23532. Abstract

Gnanakaran S, Bhattacharya T, Daniels M, Keele BF, Hraber PT, Lapedes AS, Shen T, Gaschen B, Krishnamoorthy M, Li H, Decker JM, Salazar-Gonzalez JF, Wang S, Jiang C, Gao F, Swanstrom R, Anderson JA, Ping LH, Cohen MS, Markowitz M, Goepfert PA, Saag MS, Eron JJ, Hicks CB, Blattner WA, Tomaras GD, Asmal M, Letvin NL, Gilbert PB, Decamp AC, Magaret CA, Schief WR, Ban YE, Zhang M, Soderberg KA, Sodroski JG, Haynes BF, Shaw GM, Hahn BH, Korber B. Recurrent Signature Patterns in HIV-1 B Clade Envelope Glycoproteins Associated with either Early or Chronic Infections. PLoS Pathog. 2011 Sep;7(9):e1002209. Abstract

Alam SM, Liao HX, Dennison SM, Jaeger F, Parks R, Anasti K, Foulger A, Donathan M, Lucas J, Verkoczy L, Nicely N, Tomaras GD, Kelsoe G, Chen B, Kepler TB, Haynes BF. Differential reactivity of germline allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation. J Virol. 2011 Sep 14. [Epub ahead of print] Abstract

Fouda GG, Yates NL, Pollara J, Shen X, Overman GR, Mahlokozera T, Wilks AB, Kang HH, Salazar-Gonzalez JF, Salazar MG, Kalilani L, Meshnick SR, Hahn BH, Shaw GM, Lovingood RV, Denny TN, Haynes B, Letvin NL, Ferrari G, Montefiori DC, Tomaras GD, Permar SR; Center for HIV/AIDS Vaccine Immunology. HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. J Virol. 2011 Sep. 85(18): 9555-67. Abstract

Salazar-Gonzalez JF, Salazar MG, Learn GH, Kang HH, Mahlokozera T, Kalilani L, Meshnick SR, Lovingood RV, Denny TN, Letvin NL, Shaw GM, Hahn BH and Permar SR. Limited compartmentalization, yet evidence of local production of HIV variants in breast milk of chronically HIV-infected, lactating women. J. Virol. In press, 2011.

Gnanakaran S, Bhattacharya T, Daniels M, Keele BF, Hraber P, Lapedes A, Shen T, Zhang M, Gaschen B, Li H, Salazar-Gonzalez JF, Wang S, Williamson C, Gao F, Swanstrom R, Anderson J, Cohen M, Markowitz M, Goepfert PA, Saag MS, Eron JJ, Hicks CB, Blattner WA, Tomaras GD, Asmal M, Letvin NL, Gilbert P, Magaret C, Haynes BF, Shaw GM, Hahn BH, Korber BT. Transmission signatures and patterns of recurrent change in chronic infection in HIV-1 B clade envelope proteins. PLoS Pathog. In press, 2011.

Ma BJ, Alam SM, Go EP, Desaire H, Kepler TB, Liao HX, Haynes BF. Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Membrane Proximal External Region Neutralizing Epitopes for Broad Neutralizing Antibodies and Their Reverted Unmutated Ancestors. PLoS Pathog.  2011 Sep. 7(9): e1002200.

Alam SM, Liao HX, Dennison SM, Jaeger F, Parks R, Anasti K, Foulger A, Donathan M, Lucas J, Verkoczy L, Nicely N, Tomaras GD, Kelsoe G, Chen B, Kepler TB, Haynes BF. Differential reactivity of germline allelic variants of a broadly neutralizing HIV-1 antibody to gp41 fusion intermediate conformation. J Virol. 2011 Sep 14. Epub ahead of print.

Forthal DN, Landucci G, Ding H, Kappes JC, Wang A, Thung I, Phan TB. IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is differentially affected by gp120 glycosylation. AIDS. 2011 Aug 9. Epub ahead of print.

Zhu Z, Qin HR, Chen W, Zhao Q, Shen X, Schutte R, Wang Y, Ofek G, Streaker E, Prabakaran P, Fouda GG, Liao HX, Owens J, Louder M, Yang Y, Klaric KA, Moody MA, Mascola JR, Scott JK, Kwong PD, Montefiori D, Haynes BF, Tomaras GD, Dimitrov DS. Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. J Virol. 2011 Aug 31. Epub ahead of print.

Liu P, Overman RG, Yates NL, Alam SM, Vandergrift N, Chen Y, Graw F, Freel SA, Kappes JC, Ochsenbauer C, Montefiori DC, Gao F, Perelson AS, Cohen MS, Haynes BF, Tomaras GD. Dynamic Antibody Specificities and Virion Concentrations in Circulating Immune Complexes in Acute to Chronic HIV-1 Infection. J Virol. 2011 Aug 24. Epub ahead of print.

Tomaras GD, Binley JM, Gray ES, Crooks ET, Osawa K, Moore PL, Tumba N, Tong T, Shen X, Yates NL, Decker J, Wibmer K, Gao F, Alam SM, Easterbrook P, Abdool-Karim S, Kamanga G, Crump JA, Cohen M, Shaw GM, Mascola JR, Haynes BF, Montefiori DC, Morris L. Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-infected Individuals. J Virol. 2011 Aug 17. Epub ahead of print.

Yates NL, Lucas JT, Nolen T, Vandergrift N, Soderberg K, Seaton KE, Denny TN, Haynes BF, Cohen M, Tomaras GD. Multiple HIV-1 specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV Infection. AIDS. 2011 Aug 9. [Epub ahead of print]

Asmal M, Hellmann I, Liu W, Keele BF, Perelson AS, Bhattacharya T, Gnanakaran S, Daniels M, Haynes BF, Korber BT, Hahn BH, Shaw GM, Letvin NL. A Signature in HIV-1 Envelope Leader Peptide Associated with Transition from Acute to Chronic Infection Impacts Envelope Processing and Infectivity. PLoS One. 2011. 6(8):e23673.

Persephone Borrow. Innate immunity in acute HIV-1 infection. Curr Opin HIV AIDS. 2011 Sep. 6(5): 353-63.

Jiang C, Parrish NF, Wilen CB, Li H, Chen Y, Pavlicek JW, Berg A, Lu X, Song H, Tilton JC, Pfaff JM, Henning EA, Decker JM, Moody MA, Drinker MS, Schutte R, Freel S, Tomaras GD, Nedellec R, Mosier DE, Haynes BF, Shaw GM, Hahn BH, Doms RW, Gao F. Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism. J Virol. 2011 Oct. 85(20): 10669-81.

Gillard GO, Bivas-Benita M, Hovav A-H, Grandpre LE, Panas MW, et al. 2011 Thy1+ Nk Cells from Vaccinia Virus-Primed Mice Confer Protection against Vaccinia Virus Challenge in the Absence of Adaptive Lymphocytes. PLoS Pathog. 7(8): e1002141.

Wilen CB, Parrish NF, Pfaff JM, Decker JM, Henning EA, Haim H, Petersen JE, Wojcechowskyj JA, Sodroski J, Haynes BF, Montefiori DC, Tilton JC, Shaw GM, Hahn BH, Doms RW. Phenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins. J Virol. 2011 Sep. 85(17): 8514-27.

Li Y, O'Dell S, Walker LM, Wu X, Guenaga J, Feng Y, Schmidt SD, McKee K, Louder MK, Ledgerwood JE, Graham BS, Haynes BF, Burton DR, Wyatt RT, Mascola JR. Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01. J Virol. 2011 Sep. 85(17): 8954-67.

Bonsignori M, Hwang KK, Chen X, Tsao CY, Morris L, Gray E, Marshall DJ, Crump JA, Kapiga SH, Sam NE, Sinangil F, Pancera M, Yongping Y, Zhang B, Zhu J, Kwong PD, O'Dell S, Mascola JR, Wu L, Nabel GJ, Phogat S, Seaman MS, Whitesides JF, Moody MA, Kelsoe G, Yang X, Sodroski J, Shaw GM, Montefiori D, Kepler TB, Tomaras GD, Alam SM, Liao HX, Haynes BF. Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors. J Virol. 2011 Oct. 85(19): 9998-10009.

Reeves RK, Rajakumer PA, Evans TI, Connole M, Gillis J, Wong FE, Kuzmichev YV, Carville A, Johnson RP. Depletion and dysfunction of IL-17-secreting mucosal NKp44+ NK cells during chronic SIV infection. Blood. 2011 Sep 22. 118(12): 3321-30.

Wilks AB, Perry JR, Ehlinger EP, Zahn RC, White R, Gauduin MC, Carville A, Seaman MS, Schmitz JE, Permar SR.  High cell-free virus load and robust autologous humoral immune responses in breast milk of simian immunodeficiency virus (SIV)-infected African green monkeys. J Virol. 2011 Sep. 85(18): 9517-26.

Fouda GG, Yates NL, Pollara J, Overman G, Mahlokozera T, Wilks AB, Kang HH, Salazar-Gonzales JF, Salazar MG, Kalilani L, Meshnick SR, Hahn BH, Shaw GM, Lovingood RV, Denny TN, Letvin N, Ferrari G, Tomaras GD, Montefiori DC, Permar SR and the Center for HIV/AIDS Vaccine Immunology. HIV-specific functional antibody responses in breast milk mirror those in plasma and are mediated by IgG antibodies. J. Immunol. 2011 Sep. 85(18): 9555-67.

Ganusov VV, Goonetilleke N, Liu M, Ferrari G, Shaw GM, McMichael AJ, Borrow P, Korber BT, Perelson A. Fitness costs and diversity of CTL response determine the rate of CTL escape during the acute and chronic phases of HIV infection. J Virol. Oct. 85(20): 10518-28.

Tang H, Robinson JE, Gnanakaran S, Li M, Rosenberg ES, Perez LG, Haynes BF, Liao HX, Labranche CC, Korber BT, Montefiori DC. Epitopes Immediately below the Base of the V3 Loop of gp120 as Targets for the Initial Autologous Neutralizing Antibody Response in Two HIV-1 Subtype B-Infected Individuals. J Virol. 2011 Sep. 85(18): 9286-99.

Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, Chen X, Longo NS, Louder M, McKee K, O'Dell S, Perfetto S, Schmidt SD, Shi W, Wu L, Yang Y, Yang ZY, Yang Z, Zhang Z, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Simek M, Burton DR, Koff WC, Doria-Rose N, Connors M; NISC Comparative Sequencing Program, Mullikin JC, Nabel GJ, Roederer M, Shapiro L, Kwong PD, Mascola JR. Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing. Science. 2011 Sep 16. 333(6049): 1593-602.

Gray ES, Moody MA, Wibmer CK, Chen X, Marshall D, Amos J, Moore PL, Foulger A, Yu JS, Lambson B, Abdool Karim S, Whitesides J, Tomaras GD, Haynes BF, Morris L, Liao HX. Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual. J Virol. 2011 Aug. 85(15): 7719-29.

Go EP, Hewawasam GS, Liao HX, Sutherland LL, Swanstrom R, Anderson JA, Shaw GM, Hahn BH, Haynes BF, Desaire H. Characterization of Glycosylation Profiles of HIV-1 Transmitted/Founder Envelopes by Mass Spectrometry. J. Virol. Aug. 85(16): 8270-84.

Haddow LJ, Dibben O, Moosa MYS, N’dungu T, Borrow P and Easterbrook PJ. Circulating inflammatory biomarkers may predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). AIDS. 2011 Jun 1. 25(9): 1163-74.

Mahlokozera T, Kang HH, Goonetilleke N, Stacey AR, Lovingood RV, Denny TN, Kalilani L, Bunn JEG, Meshnick SR, Borrow P, Letvin NL, Permar SR and the Center for HIV/AIDS Vaccine Immunology. The magnitude and kinetics of the mucosal immunodominant HIV-specific CD8+ T lymphocyte response and virus load in breast milk. PLoS One. 2011. 6(8): e23735.

Ferrari G, J Pollara, D Kozink, T Harms, M Drinker, MA Moody, JC Kappes, C Ochsenbauer, GM Shaw, JA Hoxie, JE Robinson, and BF Haynes.  An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum. J Virol. 2011 Jul. 85(14): 7029-36.

Brackenridge S, Evans EJ, Toebes M, Goonetilleke N, Liu MKP, de Gleria K, Schumacher TN, Davis SJ, McMichael AJ, Gillespie GM. An early HIV escape mutation within a HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1 (KIR3DL1). J Virol. 2011 Jun. 85(11): 5415-22.

Gray ES, Madiga M, Hermanus T, Moore PL, Wibmer CK, Tumba NL, Werner L, Mlisana K, Sibeko S, Williamson C, Abdool Karim S, Morris L and the CAPRISA 002 study team. HIV-1 neutralization breadth develops incrementally over 4 years and is associated with CD4+ T cell decline and high viral load during acute infection. J. Virol. J Virol. 2011 May. 85(10): 4828-40.

Dugast AS, Tonelli A, Berger CT, Ackerman ME, Sciaranghella G, Liu Q, Sips M, Toth I, Piechocka-Trocha A, Ghebremichael M, Alter G. Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals. Virology. 2011 Jul 5. 415(2): 160-7.

Moore PL, Gray ES, Sheward D, Madiga M, Ranchobe M, Lai Z, Honnen WJ,  Nonyane M, Tumba N, Hermanus T, Sibeko S, Mlisana K, Abdool Karim S, Williamson C, Pinter A, Morris L.  Potent and broad neutralization of HIV-1 subtype C 1 viruses by plasma antibodies targeting a quaternary epitope including residues in the V2 loop. J. Virol. 2011 Apr. 85(7): 3128-41.

Turnbull EL, S Wang, KE Conrod, J Baalwa, X Wei, MWong, J Turner, P Pellegrino, I Williams, GM Shaw, and P Borrow. Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary HIV-1 infection. Retrovirology. 2011 Jun 2. 8:41.

Shen R, Meng G, Ochsenbauer C, Clapham PR, Grams J, Novak L, Kappes JC, Smythies LE, Smith PD. Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages. PLoS Pathog. 2011 May. 7(5): e1002060.

Cohen MS, GM Shaw, AJ McMichael, and BF Haynes.  Acute HIV-1 infection – basic, clinical and public health perspectives. New Eng. J. Med. 2011 May 19. 364(20): 1943-54. Review.

Gay CL, Mayo AJ, Mfalila CK, Chu H, Barry AC, Kuruc JD, Mcgee KS, Kerkau M, Sebastian J, Fiscus SA, Margolis DM, Hicks CB, Ferrari G, Eron JJ, The Duke-UNC Acute HIV Infection Consortium. Efficacy of NNRTI-Based Antiretroviral Therapy Initiated During Acute HIV Infection. AIDS. 2011 Apr 24. 25(7): 941-9.

Haim H, Strack B, Kassa A, Madani N, Wang L, Courter J, Princiotto A, McGee K, Pacheco B, Seaman M, Smith III AB, Sodroski J.  Contribution of intrinsic envelope glycoprotein reactivity to CD4 independence and global inhibitor sensitivity of human immunodeficiency virus (HIV-1). PLoS Pathog. 2011 Jun. 7(6): e1002101.

Sun Y, Asmal M, Lane S, Permar SR, Schmidt SD, Mascola JR, Letvin NL. Antibody-Dependent Cell-Mediated Cytotoxicity in Simian Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol. 2011 Jul. 85(14): 6906-12.

Asmal M, Sun Y, Lane S, Yeh W, Schmidt SD, Mascola JR, Letvin NL. Antibody-dependent cell-mediated viral inhibition emerges after SIVmac251 infection of rhesus monkeys coincident with gp140 binding antibodies and is effective against neutralization-resistant viruses. J. Virol. 2011 Jun. 85(11): 5465-75.

Ge D, Ruzzo EK, Shianna KV, He M, Pelak K, Heinzen EL, Need AC, Cirulli ET, Maia JM, Dickson SP, Zhu M, Singh A, Allen AS, Goldstein DB. SVA: Software for Annotating and Visualizing Sequenced Human Genomes. Bioinformatics. 2011 Jul 15. 27(14): 1998-2000.

Whittle JR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao HX, Harrison SC. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci U S A. 2011 Aug 23. 108(34): 14216-21.

Pollara J, Hart L, Brewer F, Pickeral J, Packard BZ, Hoxie JA, Komoriya A, Ochsenbauer C, Kappes JC, Roederer M, Huang Y, Weinhold KJ, Tomaras GD, Haynes BF, Montefiori DC, Ferrari G. High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses. Cytometry A. 2011 Aug. 79(8): 603-12.

Gray ES, Moody MA, Wibmer CK, Chen X, Marshall D, Amos J, Moore PL, Foulger A, Yu JS, Lambson B, Abdool Karim S, Whitesides J, Tomaras GD, Haynes BF, Morris L, Liao HX. Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual. J Virol. 2011 Aug. 85(15): 7719-29.

Letvin NL, JR Mascola, DC Montefiori, MS Seaman, Y Sun, WW Yeh, M Asmal, RS Gelman. S-Y Lim, L Shen, JB Whitney, C Seoighe, M Lacerda, S Keating, PJ Norris, MG Hudgens, PB Gilbert, AP Buzby, LV Mach, J Zhang, H Balachandran, GM Shaw, S Schmidt, J-P Todd, A Dodson, SS Rao, GJ Nabel.  Immune and genetic correlates of vaccine protection against SIVsmE660 mucosal infection in rhesus monkeys.  Sci Transl Med. 2011 May 4. 3(81): 81ra36.

Gay C, Dibben O, Anderson J, Stacey A, Norris P, Mayo AJ, Kuruc J, Salazar-Gonzalez JF, Li H, Keele BF, Hicks C, Margolis D, Ferrari G, Haynes BF, Swanstrom R, Shaw GM, Hahn BH, Eron JJ, Borrow P, Cohen MS. Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy. PLoS One. 2011 May 10. 6(5): e19617.

Ranasinghe SR, Kramer HB, Wright C, Kessler BM, di Gleria K, Zhang Y, Gillespie GM, Blais ME, Culshaw A, Pichulik T, Simmons A, Rowland-Jones SL, McMichael AJ, Dong T. The antiviral efficacy of HIV-specific CD8+ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate. PLoS Pathog. 2011 May. 7(5): e1001341.

Wu X, Changela A, O'Dell S, Schmidt SD, Pancera M, Yang Y,Zhang B, Gorny MK, Phogat S, Robinson JE, Stamatatos L, Zolla-Pazner S, Kwong PD, Mascola JR. Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies. J Virol. 2011 May. 85(9): 4578-85.

Dennison SM, Anasti K, Scearce RM, Sutherland L, Parks R, Xia SM, Liao HX, Gorny MK, Zolla-Pazner S, Haynes BF, Alam SM.  Non-neutralizing HIV-1 gp41 envelope cluster 1 II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. J. Virol. 2011 Feb. 85(3): 1340-7.

Jiang H, Hester CG, Liao L, Montefiori DC, Frank MM. Erratum to: Mechanisms by which HIV envelope minimizes immunogenicity. Immunol Res. 2011 Jan 12. [Epub ahead of print] 

Salazar-Gonzalez JF, Salazar MG, Learn GH, Fouda GG, Kang HH, Mahlokozera T, Wilks AB, Lovingood RV, Stacey A, Kalilani L, Meshnick SR, Borrow P, Montefiori DC, Denny TN, Letvin NL, Shaw GM, Hahn BH, Permar SR; Center for HIV/AIDS Vaccine Immunology A0167854. Origin and Evolution of HIV-1 in Breast Milk Determined by Single-Genome Amplification and Sequencing. J. Virol. 2011 Mar. 85(6): 2751-63.

Ferrari G, Korber B, Goonetilleke N, Liu MK, Turnbull EL, Salazar-Gonzalez JF, Hawkins N, Self S, Watson S, Betts MR, Gay C, McGhee K, Pellegrino P, Williams I, Tomaras GD, Haynes BF, Gray CM, Borrow P, Roederer M, McMichael AJ, Weinhold KJ. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog. 2011 Feb 10. 7(2): e1001273.

Ritchie AJ, Campion SL, Kopycinski J, Moodie Z, Wang ZM, Pandya K, Moore S, Liu MK, Brackenridge S, Kuldanek K, Legg K, Cohen MS, Delwart EL, Haynes BF, Fidler S, McMichael AJ, Goonetilleke N. Differences in HIV specific T cell responses between HIV seronegative exposed and unexposed individuals. J Virol. 2011 Jan 26. [Epub ahead of print]

Fellay J, Frahm N, Shianna KV, Cirulli ET, Casimiro DR, Robertson MN, Haynes BF, Geraghty DE, McElrath MJ, Goldstein DB; for the National Institute of Allergy and Infectious Diseases (NIAID) Center for HIV/AIDS Vaccine Immunology (CHAVI) and the NIAID HIV Vaccine Trials Network (HVTN). Host Genetic Determinants of T Cell Responses to the MRKAd5 HIV-1 gag/pol/nef Vaccine in the Step Trial. J. Infect. Dis. 2011 Mar. 203(6): 773-779.

Corrah TW, Goonetilleke N, Kopycinski J, Deeks SG, Cohen MS, Borrow P, McMichael A, Brackenridge S. A reappraisal of the relationship between the HIV-protective single nucleotide polymorphism 35kb upstream of the HLA-C gene and surface HLA-C expression. J. Virol. 2011 Jan 19. [Epub ahead of print]

Campion S, Cohen MS, McMichael AJ, Galvin S, Goonetilleke N. Improved detection of latent Mycobacterium tuberculosis infection in HIV-1 seropositive individuals using cultured cellular assays. Eur. J. Immunol. 2011 Jan. 41(1): 255-7.

Freel SA, Saunders KO, Tomaras GD. CD8(+) T-cell-mediated control of HIV-1 and SIV infection. Immunol. Res. 2011 Apr. 49(1-3): 135-46.

O’Brien M, Manches O, Sabado RL, Baranda SJ, Wang Y, Marie I, Rolnitzky L, Markowitz M, Margolis DM, Levy D, and Bhardwaj N. Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFNγ-producing and partially matured phenotype. J. Clin. Invest. 2011 Mar 1. 121(3): 1088-101.

Kirchherr JL, Hamilton J, Lu X, Gnanakaran S, Muldoon M, Daniels M, Kasongo W, Chalwe V, Mulenga C, Mwananyanda L, Musonda RM, Yuan X, Montefiori DC, Korber BT, Haynes BF, Gao F. Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120. Virology. 2011 Jan 20. 409(2): 163-74.

Reeves RK, Evans TI, Fultz PN, Johnson RP. Potential confusion of contaminating CD16+ mDCs with anergic CD16+ NK cells in chimpanzees. Eur. J. Immunol. 2011 Feb 11. [Epub ahead of print]

Reeves RK, Evans TI, Gillis J, Wong FE, Connole M, Carville A, Johnson RP. Quantification of mucosal mononuclear cells with a fluorescent bead-based polychromatic flow cytometry assay. J. Immunol. Methods. 2011 Feb 18. [Epub ahead of print]

Petrovski S, Fellay J, Shianna KV, Carpenetti N, Kumwenda J, Kamanga G, Kamwendo DD, Letvin NL, McMichael AJ, Haynes BF, Cohen MS, Goldstein DB; Center for HIV/AIDS Vaccine Immunology. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. AIDS. 2011 Feb 20. 25(4): 513-8.

Jimenez-Baranda S, Greenbaum B, Manches O, Handler J, Rabadan R, Levine A, Bhardwaj N. Oligonucleotide Motifs That Disappear During the Evolution of Influenza in Humans Increase IFN-α secretion by Plasmacytoid Dendritic Cells. J. Virol. 2011 Feb 9. [Epub ahead of print]

Cale EM, Hraber P, Giorgi EE, Fischer W, Bhattacharya T, Leitner T, Yeh WW, Gleasner C, Green LD, Han CS, Korber B, Letvin NL. Epitope-specific CD8+ T lymphocytes cross-recognize mutant SIV sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection. J. Virol. 2011 Feb 9. [Epub ahead of print]

Altfeld M, Fadda L, Frleta D, Bhardwaj N. DCs and NK cells: critical effectors in the immune response to HIV-1. Nat. Rev. Immunol. 2011 Mar. 11(3): 176-86.

2010 Publications

McMichael AJ, Jones EY. Genetics. First-class control of HIV-1. Science. 2010 Dec 10. 330(6010): 1488-90. No abstract available

Petrovski S, Fellay J, Shianna KV, Carpenetti N, Kumwenda J, Kamanga G, Kamwendo DD, Letvin NL, McMichael AJ, Haynes BF, Cohen MS, Goldstein DB; on behalf of the Center for HIV/AIDS Vaccine Immunology (CHAVI). Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. AIDS. 2010 Dec 14. [Epub ahead of print] Abstract

Haynes BF, Moody MA, Liao HX, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med. 2010 Nov 25. [Epub ahead of print] Abstract

Dennison SM, Anasti K, Scearce RM, Sutherland L, Parks R, Xia SM, Liao HX, Gorny MK, Zolla-Pazner S, Haynes BF, Alam SM. Non-neutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. J Virol. 2010 Nov 24. [Epub ahead of print]Abstract

Kirchherr JL, Hamilton J, Lu X, Gnanakaran S, Muldoon M, Daniels M, Kasongo W, Chalwe V, Mulenga C, Mwananyanda L, Musonda RM, Yuan X, Montefiori DC, Korber BT, Haynes BF, Gao F. Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120. Virology. 2010 Oct 29. [Epub ahead of print] Abstract

McElrath MJ, Haynes BF. Induction of immunity to human immunodeficiency virus type-1 by vaccination. Immunity. 2010 Oct 29. 33(4): 542-54. Abstract

Alter G, Moody MA. The humoral response to HIV-1: new insights, renewed focus. J Infect Dis. 2010 Oct 15. 202 Suppl 2:S315-22. Review. Abstract

Cohen MS, Gay CL, Busch MP, Hecht FM. The detection of acute HIV infection. J Infect Dis. 2010 Oct 15;202 Suppl 2:S270-7. Review. Abstract

Fellay J, Shianna KV, Telenti A, Goldstein DB. Host Genetics and HIV-1: The Final Phase? PLoS Pathog. 6(10):e1001033. Full Text

Gnanakaran S, Daniels MG, Bhattacharya T, Lapedes AS, Sethi A, Li M, Tang H, Greene K, Gao H, Haynes BF, Cohen MS, Shaw GM, Seaman MS, Kumar A, Gao F, Montefiori DC, Korber B. Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies. PLoS Comput Biol. 2010 Oct 7. 6(10):e1000955. Full Text

Liu J, Keele BF, Li H, Keating S, Norris PJ, Carville A, Mansfield KG, Tomaras GD, Haynes BF, Kolodkin-Gal D, Letvin NL, Hahn BH, Shaw GM, Barouch DH. Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. J Virol. 2010 Oct. 84(19):10406-12. Abstract

Pelak K, Shianna KV, Ge D, Maia JM, Zhu M, Smith JP, Cirulli ET, Fellay J, Dickson SP, Gumbs CE, Heinzen EL, Need AC, Ruzzo EK, Singh A, Campbell CR, Hong LK, Lornsen KA, McKenzie AM, Sobreira NL, Hoover-Fong JE, Milner JD, Ottman R, Haynes BF, Goedert JJ, Goldstein DB. The characterization of twenty sequenced human genomes. PLoS Genet. 2010 Sep 9. 6(9): e1001111. Full Text

Fischer W, Ganusov VV, Giorgi EE, Hraber PT, Keele BF, Leitner T, Han CS, Gleasner CD, Green L, Lo CC, Nag A, Wallstrom TC, Wang S, McMichael AJ, Haynes BF, Hahn BH, Perelson AS, Borrow P, Shaw GM, Bhattacharya T, Korber BT. Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing. PLoS One. 2010 Aug 20. 5(8). Full Text

Lim SY, Chan T, Gelman RS, Whitney JB, O'Brien KL, Barouch DH, Goldstein DB, Haynes BF, Letvin NL. Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 2010 Jun 24. 6(6): e1000997. Full Text

Bar KJ, Li H, Chamberland A, Tremblay C, Routy JP, Grayson T, Sun C, Wang S, Learn GH, Morgan CJ, Schumacher JE, Haynes BF, Keele BF, Hahn BH, Shaw GM. Wide variation in the multiplicity of HIV-1 infection among injection drug users. J Virol. 2010 Jun. 84(12): 6241-7. Abstract

Li H, Bar KJ, Wang S, Decker JM, Chen Y, Sun C, Salazar-Gonzalez JF, Salazar MG, Learn GH, Morgan CJ, Schumacher JE, Hraber P, Giorgi EE, Bhattacharya T, Korber BT, Perelson AS, Eron JJ, Cohen MS, Hicks CB, Haynes BF, Markowitz M, Keele BF, Hahn BH, Shaw GM. High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. PLoS Pathog. 2010 May 13. 6(5): e1000890. Full Text

Kramer HB, Lavender KJ, Qin L, Stacey AR, Liu MK, di Gleria K, Simmons A, Gasper-Smith N, Haynes BF, McMichael AJ, Borrow P, Kessler BM. Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. PLoS Pathog. 2010 May 6. 6(5): e1000893. Full Text

Moody MA, Liao HX, Alam SM, Scearce RM, Plonk MK, Kozink DM, Drinker MS, Zhang R, Xia SM, Sutherland LL, Tomaras GD, Giles IP, Kappes JC, Ochsenbauer-Jambor C, Edmonds TG, Soares M, Barbero G, Forthal DN, Landucci G, Chang C, King SW, Kavlie A, Denny TN, Hwang KK, Chen PP, Thorpe PE, Montefiori DC, Haynes BF. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. J Exp Med. 2010 Apr 12. 207(4): 763-76. Abstract

Pelak K, Goldstein DB, Walley NM, Fellay J, Ge D, Shianna KV, Gumbs C, Gao X, Maia JM, Cronin KD, Hussain SK, Carrington M, Michael NL, Weintrob AC. Host Determinants of HIV-1 Control in African Americans. J Infect Dis. 2010 Mar 5. Epub ahead of print. Abstract

Cella M, Presti R, Vermi W, Lavender K, Turnbull E, Ochsenbauer-Jambor C, Kappes JC, Ferrari G, Kessels L, Williams I, McMichael AJ, Haynes BF, Borrow P, Colonna M; CHAVI Clinical Core B; the NIAID Center for HIV/AIDS Vaccine Immunology. Loss of DNAM-1 contributes to CD8(+) T cell exhaustion in chronic HIV-1 infection. Eur J Immunol. 2010 Mar 3. Epub ahead of print. Abstract

Freel SA, Lamoreaux L, Chattopadhyay PK, Saunders K, Zarkowsky D, Overman RG, Ochsenbauer C, Edmonds TG, Kappes JC, Cunningham CK, Denny TN, Weinhold KJ, Ferrari G, Haynes BF, Koup RA, Graham BS, Roederer M, Tomaras GD. Phenotypic and Functional Profile of HIV-inhibitory CD8 T cells Elicited by Natural Infection and Heterologous Prime/boost Vaccination. J Virol. 2010 Mar 3. Epub ahead of print. Abstract

Santra S, Liao HX, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A, Quinn D, Parks RJ, Tsao CY, Carville A, Mansfield KG, Pavlakis GN, Felber BK, Haynes BF, Korber BT, Letvin NL. Mosaic vaccines elicit CD8(+) T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med. 2010 Feb 21. Epub ahead of print. Abstract

McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol. 2010 Jan. 10(1): 11-23. Epub 2009 Dec 11. Abstract

Yoon W, Ma BJ, Fellay J, Huang W, Xia SM, Zhang R, Shianna KV, Liao HX, Haynes BF, Goldstein DB; NIAID Center for HIV/AIDS Vaccine Immunology. A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. AIDS. 2010 Jan 2. 24(1): 155-7. Abstract

Nandi A, Lavine CL, Wang P, Lipchina I, Goepfert PA, Shaw GM, Tomaras GD, Montefiori DC, Haynes BF, Easterbrook P, Robinson JE, Sodroski JG, Yang X; NIAID Center for HIV/AIDS Vaccine Immunology. Epitopes for broad and potent neutralizing antibody responses during chronic infection with human immunodeficiency virus type 1. Virology. 2010 Jan 20. 396(2): 339-48. Epub 2009 Nov 17. Abstract

2009 Publications

Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). Common genetic variation and the control of HIV-1 in humans. PLoS Genet. 2009 Dec. 5(12): e1000791. Abstract

Verkoczy L, Diaz M, Holl TM, Ouyang Y-B, Bouton-Verville H, Alam SM, Liao H-X, Kelsoe G, Haynes BF. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. PNAS.Published online before print December 14, 2009. Abstract

Alam SM, Morelli M, Dennison SM, Liao HX, Zhang R, Xia SM, Rits-Volloch S, Sun L, Harrison SC, Haynes BF, Chen B. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2009 Nov 11. Abstract

Lee HY, Giorgi EE, Keele BF, Gaschen B, Athreya GS, Salazar-Gonzalez JF, Pham KT, Goepfert PA, Kilby JM, Saag MS, Delwart EL, Busch MP, Hahn BH, Shaw GM, Korber BT, Bhattacharya T, Perelson AS. Modeling sequence evolution in acute HIV-1 infection. J Theor Biol. 2009 Nov 21. 261(2): 341-60. Abstract

Khurana S, Norris PJ, Busch MP, Haynes BF, Park S, Sasono P, Mlisana K, Salim AK, Hecht FM, Mulenga J, Chomba E, Hunter E, Allen S, Nemo G, Rodriguez-Chavez IR; Women's Interagency HIV Study; Joseph B. Margolick on behalf of Multicenter AIDS Cohort Study (MACS), Golding H. HIV-Selectest EIA and Rapid Test: Ability to Detect Seroconversion Following HIV-1 Infection. J Clin Microbiol. 2009 Nov 11. Abstract

Dennison SM, Stewart SM, Stempel KC, Liao HX, Haynes BF, Alam SM. Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. J Virol. 2009 Oct. 83(19): 10211-23. Epub 2009 Jul 29. Abstract

Urban TJ, Weintrob AC, Fellay J, Colombo S, Shianna KV, Gumbs C, Rotger M, Pelak K, Dang KK, Detels R, Martinson JJ, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Telenti A, Michael NL, Goldstein DB. CCL3L1 and HIV/AIDS susceptibility. Nat Med. 2009 Oct. 15(10):1110-2. No abstract available.

Gao F, Scearce RM, Alam SM, Hora B, Xia S, Hohm JE, Parks RJ, Ogburn DF, Tomaras GD, Park E, Lomas WE, Maino VC, Fiscus SA, Cohen MS, Moody MA, Hahn BH, Korber BT, Liao HX, Haynes BF. Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins. Virology. 2009 Sep 8. [Epub ahead of print] Abstract

Bonsignori M, Moody MA, Parks RJ, Holl TM, Kelsoe G, Hicks CB, Vandergrift N, Tomaras GD, Haynes BF. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection. J Immunol. 2009 Aug 15. 183(4): 2708-17. Abstract

Keele BF, Jones JH, Terio KA, Estes JD, Rudicell RS, Wilson ML, Li Y, Learn GH, Beasley TM, Schumacher-Stankey JC, Wroblewski EE, Mosser A, Raphael J, Kamenya S, Lonsdorf EV, Travis DA, Mlengeya T, Kinsel MJ, Else JG, Silvestri G, Goodall J, Sharp PM, Shaw GM, Pusey AE, Hahn BH. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature. 460: 515-519 (23 July 2009) Abstract

Levesque MC, Moody MA, Hwang K-K, Marshall DJ, Whitesides JF, et al. Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection. PLoS Med. 6(7): e1000107. Full Text

Liao HX, Levesque MC, Nagel A, Dixon A, Zhang R, Walter E, Parks R, Whitesides J, Marshall DJ, Hwang KK, Yang Y, Chen X, Gao F, Munshaw S, Kepler TB, Denny T, Moody MA, Haynes BF. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods. 2009 Jun. 158(1-2): 171-9. Abstract

Gray ES, Taylor N, Wycuff D, Moore PL, Tomaras GD, Wibmer CK, Puren A, Decamp A, Gilbert PB, Wood B, Montefiori DC, Binley JM, Shaw GM, Haynes BF, Mascola JR, Morris L. Antibody specificities associated with neutralization breadth in plasma from HIV-1 subtype C infected blood donors. J Virol. 2009 Jun 24. Abstract

Salazar-Gonzalez JF, Salazar MG, Keele BF, Learn GH, Giorgi EE, Li H, Decker JM, Wang S, Baalwa J, Kraus MH, Parrish NF, Shaw KS, Guffey MB, Bar KJ, Davis KL, Ochsenbauer-Jambor C, Kappes JC, Saag MS, Cohen MS, Mulenga J, Derdeyn CA, Allen S, Hunter E, Markowitz M, Hraber P, Perelson AS, Bhattacharya T, Haynes BF, Korber BT, Hahn BH, Shaw GM. Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J Exp Med. 2009 Jun 1. Epub ahead of print. Abstract

Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, Keele BF, Learn GH, Turnbull EL, Salazar MG, Weinhold KJ, Moore S; CHAVI Clinical Core B, Letvin N, Haynes BF, Cohen MS, Hraber P, Bhattacharya T, Borrow P, Perelson AS, Hahn BH, Shaw GM, Korber BT, McMichael AJ. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J Exp Med. 2009 Jun 1. Epub ahead of print. Abstract

Sarzotti-Kelsoe M, Cox J, Cleland N, Denny T, Hural J, Needham L, Ozaki D, Rodriguez-Chavez IR, Stevens G, Stiles T, Tarragona-Fiol T, Simkins A. Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials. PLoS Med. 2009 May 26. 6(5):e1000067. Full Text

Kassa A, Finzi A, Pancera M, Courter JR, Smith AB 3rd, Sodroski J. Identification of a Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variant Resistant to Cold Inactivation. Journal of Virology. 2009 May. 83(9): 4476-88. Abstract

Davis KL, ES Gray, PL Moore, JM Decker, A Salomon, DC Montefiori, BS Graham, MC Keefer, A Pinter, L Mooris, BH Hahn, and GM Shaw. High Titer HIV-1 V3-Specific Antibodies with Broad Reactivity but Low Neutralizing Potency in Acute Infection and Following Vaccination. Virology. 2009 May 10. 387(2):414-26. Abstract

Korber BT, Letvin NL, Haynes BF. T cell Vaccine Strategies for HIV, the Virus With a Thousand Faces. J Virol. 2009 May 13. Epub ahead of print. Abstract

Wood N, Bhattacharya T, Keele BF, Giorgi E, Liu M, Gaschen B, Daniels M, Ferrari G, Haynes BF, McMichael A, Shaw GM, Hahn BH, Korber B, Seoighe C. HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. PLoS Pathog. 2009 May. 5(5):e1000414. Abstract  l  Full Text

Alter G, Rihn S, Walters K, Nolting A, Martin M, Rosenberg ES, Miller JS, Carrington M, Altfeld M. HLA class I subtype dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute HIV-1 infection. J Virol. 2009 Apr 22. Epub ahead of print. Abstract

Stacey AR, Norris PJ, Qin L, Haygreen EA, Taylor E, Heitman J, Lebedeva M, Decamp A, Li D, Grove D, Self SG, Borrow P. Induction of a striking systemic cytokine cascade prior to peak viraemia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. Journal of Virology. 2009 Apr. 83(8): 3719-33.Abstract

Shen X, Parks RJ, Montefiori DC, Kirchherr JL, Keele BF, Decker JM, Blattner WA, Gao F, Weinhold KJ, Hicks CB, Greenberg ML, Hahn BH, Shaw GM, Haynes BF, Tomaras GD. In Vivo gp41 Antibodies Targeting the 2F5 mAb Epitope Mediate HIV-1 Neutralization Breadth. Journal of Virology. 2009 Apr. 83(8): 3617-25. Abstract

Shen R, Richter HE, Clements RH, Novak L, Huff K, Bimczok D, Sankaran-Walters S, Dandekar S, Clapham PR, Smythies LE, Smith PD. Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection. J Virol. 2009 Apr. 83(7): 3258-67. Abstract

Abrahams MR, Anderson JA, Giorgi EE, Seoighe C, Mlisana K, Ping LH, Athreya GS, Treurnicht FK, Keele BF, Wood N, Salazar-Gonzalez JF, Bhattacharya T, Chu H, Hoffman I, Galvin S, Mapanje C, Kazembe P, Thebus R, Fiscus S, Hide W, Cohen MS, Karim SA, Haynes BF, Shaw GM, Hahn BH, Korber BT, Swanstrom R, Williamson C; for the CAPRISA Acute Infection Study Team and the Center for HIV-AIDS Vaccine Immunology Consortium. Quantitating the multiplicity of infection with HIV-1 subtype C reveals a non-Poisson distribution of transmitted variants. J Virol. 2009 Apr. 83(8): 3556-67. Abstract

Yuan W, Li X, Kasterka M, Gorny MK, Zolla-Pazner S and Sodroski J. Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies. AIDS Research and Human Retroviruses. 2009 Mar. 25(3): 319-28. Abstract

Yeh WW, Jaru-Ampornpan P, Nevidomskyte D, Asmal M, Rao SS, Buzby AP, Montefiori DC, Korber BT, Letvin NL. Partial protection of SIV-infected rhesus monkeys against superinfection with a heterologous SIV isolate. J Virol. 2009 Mar. 83(6): 2686-96. Abstract

Nkwanyana NN, Gumbi PP, Roberts L, Denny L, Hanekom W, Soares A, Allan B, Williamson AL, Coetzee D, Olivier AJ, Burgers WA, Passmore JA. Impact of HIV-1 infection and inflammation on composition and yield of cervical mononuclear cells in the female genital tract. AIDS Research and Human Retroviruses. In press, 2009.

Davis KL, Bibollet-Ruche F, Li H, Decker JM, Kutsch O, Morris L, Salomon A, Pinter A, Hoxie JA, Hahn BH, Kwong PD, Shaw GM. Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma. Journal of Virology. 2009 Feb. 83(3): 1240-59.Abstract

Gray CM, Mlotshwa M, Riou C, Mathebula T, de Assis Rosa D, Mashishi T, Seoighe C, Ngandu N, van Loggerenberg F, Morris L, Mlisana K, Williamson C, Karim SA; CAPRISA 002 Acute Infection Study Team. Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point. Journal of Virology. 2009 Jan. 83(1): 470-8. Abstract

Hatano H, Delwart EL, Norris PJ, Lee TH, Dunn-Williams J, Hunt PW, Hoh R, Stramer SL, Linnen JM, McCune JM, Martin JN, Busch MP, Deeks SG. Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. Journal of Virology. 2009 Jan. 83(1): 329-35.Abstract

2008 Publications

Tomaras GD, Yates NL, Liu P, Qin L, Fouda GG, Chavez LL, Decamp AC, Parks RJ, Ashley VC, Lucas JT, Cohen M, Eron J, Hicks CB, Liao HX, Self SG, Landucci G, Forthal DN, Weinhold KJ, Keele BF, Hahn BH, Greenberg ML, Morris L, Karim SS, Blattner WA, Montefiori DC, Shaw GM, Perelson AS, Haynes BF. Initial B Cell Responses to Transmitted HIV-1: Virion-Binding IgM and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia. J Virol. 2008 Dec. 82(24):12449-63. Abstract

Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, van Rooijen N, Hovav AH, Letvin NL. CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses. Blood. 2008 Dec 1. 112 (12): 4585-90. Abstract

Barnett D, Walker B, Landay AL, Denny TN. CD4 immunophenotyping in HIV infection. Nature Reviews Microbiology. 2008 November. (6)11: S7-S15. Abstract

Manches O, Munn D, Fallahi A, Lifson J, Chaperot L, Plumas J, Bhardwaj N. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism. J Clin Invest. 2008 Oct. 118(10): 3431-9.Abstract

Moody MA, Haynes BF. Antigen-specific B cell detection reagents: use and quality control. Cytometry A. 2008 Nov. 73(11): 1086-92. Review. Abstract

Permar SR, Kang HH, Carville A, Mansfield KG, Gelman RS, Rao SS, Whitney JB, Letvin NL. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys.
Journal of Immunology. 2008 Sep 1. 181(5): 3643-50. Abstract

Haynes BF and Shattock RJ. Critical Issues in mucosal immunity for HIV-1 vaccine development. J. Aller & Clin Immunol. 2008 Jul. 122(1):3-9; quiz 10-1. Abstract

Santra S, Korber BT, Muldoon M, Barouch DH, Nabel GJ, Gao F, Hahn BH, Haynes BF, Letvin NL. Centralized Gene-based HIV-1 Vaccine Elicits Broad Cross-clade Cellular Immune Responses in Rhesus Monkeys. Proceedings of the National Academy of Sciences. 2008 Jul 29. 105(30): 10489-94. Abstract

Gasper-Smith N, Crossman DM, Whitesides JF, Mensali N, Ottinger JS, Plonk SG, Moody MA, Ferrari G, Weinhold KJ, Miller SE, Reich CF 3rd, Qin L, Self SG, Shaw GM, Denny TN, Jones LE, Pisetsky DS, Haynes BF. Induction of Plasma (TRAIL), TNFR-2, Fas Ligand and Plasma Microparticles After HIV-1 Transmission: Implications for HIV-1 Vaccine Design. J Virol. 2008 Aug. 82(15):7700-10.  Abstract

Keele BF, Giorgi EE, Salazar-Gonzalez J, Decker JM, Pham KT, Salazar MG, Sun C, Grayson T, Wang S, Li H, Wei X, Jiang C, Kirchherr JL, Gao F, Anderson JA, Ping L-H, Swanstrom R, Tomaras GD, Blattner WA, Goepfert PA, Kilby JM, Saag MS, Delwart EL, Busch MP, Cohen MS, Montefiori DC, Haynes BF, Gaschen B, Athreya GS, Lee HY, Wood N, Seoighe C, Perelson AS, Bhattacharya T, Korber BT, Hahn BH, Shaw GM. Identification and Characterization of Transmitted and Early Founder Virus Envelopes in Primary HIV-1 Infection. Proceedings of the National Academy of Sciences. 2008 May 27. 105(21):7552-Abstract

Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL. Kinetics of recombinant adenovirus type 5, vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory T-lymphocyte responses. Clinical Vaccine Immunology. 2008 Apr. 15(4): 691-6. Abstract

Gray ES, Moore PL, Bibollet-Ruche F, Li H, Decker JM, Meyers T, Shaw GM, Morris L. 4E10 Resistant Variants in an HIV-1 Subtype C Infected Individual with a Strong Anti-MPER Neutralizing Antibody Response. Journal of Virology. 2008 Mar. 82(5): 2367-75. Abstract

Frey G, Peng H, Rits-Volloch S, Morelli M, Cheng Y, Chen B. A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. Proceedings of the National Academy of Sciences. 2008 Mar 11. 105(10): 3739-44. Abstract

Goldstein DB. Genomics and biology come together to fight HIV. PLoS Biology. 2008 Mar 25. 6(3): e76. Abstract

Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: Software for genomic annotation of whole genome association studies.Genome Res. 2008 Apr. 18(4):640-3. Abstract

Moore PL, Gray ES, Choge IA, Ranchobe N, Mlisana K, Abdool Karim SS, Williamson C, Morris L; CAPRISA 002 Study Team. The C3-V4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection.
Journal of Virology. 2008 Feb. 82(4): 1860-9. Abstract

Salazar-Gonzalez JF, Bailes E, Pham KT, Salazar MG, Guffey MB, Keele BF, Derdeyn CA, Farmer P, Hunter E, Allen S, Manigart O, Mulenga J, Anderson JA, Swanstrom R, Haynes BF, Athreya GS, Korber BT, Sharp PM, Shaw GM, Hahn BH. Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single Genome Amplification and Sequencing. Journal of Virology. 2008 Apr. 82(8):3952-70. Abstract

Haynes BF and Alam SM. HIV hides an Achillees’ Heel in virion lipids. Immunity. 2008 Jan. 28(1):10-2. Abstract

Alam SM, Scearce R, Parks R, Plonk P, Plonk SG, Sutherland LL, Gorny MK,  Zolla-Pazner S, VanLeeuwen S, Moody MA, Xia S-X, Montefiori DC, Tomaras  GD, Weinhold KJ, Karim, SA, Hicks CB, Liao H-X, Robinson J, Shaw G.M., and Haynes BF. HIV-1 gp41 Antibodies That Mask Membrane Proximal Neutralizing Epitopes: Antibody Binding Kinetics, Induction And Potential For Regulation in Acute Infection.J Virol. 2008 Jan. 82(1):115-25. Abstract

2007 Publications

Powers KA, Miller WC, Pilcher CD, Mapanje C, Martinson FEA, Fiscus SA, Chilongozi D, Namakhwa D, Gama S, Price M, Galvin S, Hoffman I and Cohen MS. A risk score algorithm for detecting acute HIV-1 infection in an African STI clinic. AIDS. 2007 Oct 18. 21(16):2237-42. Abstract

Borrow P and Bhardwaj N. Innate immune responses in primary HIV-1 infection.Current Opinion in HIV and AIDS. 2008 Jan;3(1):36-44.

Hovav AH, Panas MW, Osuna CE, Cayabyab MJ, Autissier P, Letvin NL. The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells.Journal of Virology. 2007 Dec. 81(23): 12793-802. Abstract

Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL. Duration of Antigen Expression In Vivo following DNA Immunization Modifies the Magnitude, Contraction, and Secondary Responses of CD8+ T Lymphocytes. Journal of Immunology. 2007 Nov 15. 179(10): 6725-33. Abstract

Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.Science. 2007 Sep 28. 317(5846): 1930-4. Abstract

Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR. Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nat Med. 2007 Sep. 13(9):1032-4.  Abstract

Pilcher CD, Joaki G, Hoffman IF, Martinson FEA, Mapanje C, Stewart PW, Powers KA, Galvin S, Chilongozi D, Gama S, Price MA, Fiscus SA, and Cohen MS. Amplified transmission of HIV-1: Comparison of HIV-1 concentrations in blood and semen in acute and chronic infection. AIDS. 2007 Aug 20. 21(13): 1723-30. Abstract

Jones LE and Perelson AS. Transient viremia and reservoir replenishment in HIV infected patients on antiretroviral therapy. JAIDS. 2007 Aug 15. 45(5): 483-93. Abstract

Sun Y, Permar, SR, Buzby, AP, Letvin, NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol. 2007 Aug; 81(15):8009-15. Epub 2007 May 23. Abstract

Hicks CB, Gay C, and Ferrari G. Acute HIV infection: the impact of anti-retroviral treatment on cellular immune responses. 
Clinical and Experimental Immunology. 2007 Aug. 149(2): 211-6. Abstract

Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB. A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1.Science. 2007 Jul 19 [Epub ahead of print]. Abstract

Kirchherr JL, Lu X, Kasongo W, Chalwe V, Mwananyanda L, Musonda RM, Xia SM, Scearce RM, Liao HX, Montefiori DC, Haynes BF, Gao F. High-throughput functional analysis of HIV-1 env genes without cloning. Journal of Virological Methods. 2007 Jul. 143(1): 104-11. Abstract

Qin, L, Greenland, JR, Moriya, C, Cayabyab, MJ, Letvin, NL. Effects of type I interferons on the adjuvant properties of plasmid GM-CSF in vivo. J. Virol. 2007 Oct 81(19):10606-13. Epub July 25. Abstract

Fellay J and Goldstein DB. Host genetics: fine-tuning innate signaling. Curr Biol. 2007 Jul 3. 17(13): R516-8. Abstract

Dhillon AK, Donners H, Pantophlet R, Johnson WE, Decker JM, Shaw GM, Lee FH, Richman DD, Doms RW, Vanham G, Burton DR. Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human Immunodeficiency Virus Type 1-infected donors. Journal of Virology. 2007 Jun. 81(12): 6548-62. Abstract

Gray ES, Moore PL, Choge IA, Decker JM, Bibollet-Ruche F, Li H, Leseka N, Treurnicht F, Mlisana K, Shaw GM, Karim SS, Williamson C, Morris L. Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. Journal of Virology. 2007 Jun. 81(12):6187-96. Epub 2007 Apr 4. Abstract

Dey B, Pancera M, Svehla K, Shu Y, Xiang SH, Vainshtein J, Li Y, Sodroski J, Kwong PD, Mascola JR, Wyatt R. Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics and immunogenicity. Journal of Virology. 2007 Jun. 81(11): 5579-93. Abstract

Greenland, JR, Geiben, R, Ghosh, S, Pastor, WA, Letvin, NL. Plasmid DNA vaccine –elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis. J. Immunol. 178: 5652-5658, 2007. Abstract

Wilson TJ, Presti RM, Tassi I, Overton ET, Cella M, Colonna M. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood. 2007 May 1. 109(9):3786-93. Epub 2007 Jan 9. Abstract

Alam SM, McAdams M, Boren D, Rak M, Scearce RM, Gao F, Comacho ZT, Gewirth D, Kelsoe G, Chen P, Haynes BF. The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes.J. Immunol.178: 4424-35, 2007. Abstract

Kothe DL, Decker JM, Li Y, Weng Z, Bibollet-Ruche F, Zammit KP, Salazar MG, Chen Y, Salazar-Gonzalez JF, Moldoveanu Z, Mestecky J, Gao F, Haynes BF, Shaw GM, Muldoon M, Korber BT, Hahn BH. Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins. Virology. 2007 Mar 30. 360(1): 218-34. Abstract

Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature. 2007 Feb 15. 445(7129): 732-7. Abstract

Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR Jr, Letvin NL. Rapid Memory CD8+ T-Lymphocyte Induction through Priming with Recombinant Mycobacterium smegmatis. Journal of Virology. 2007 Jan. 81(1): 74-83. Abstract

2006 Publications

Telenti A, Goldstein DB. Genomics meets HIV-1. Nature Reviews Microbiology. 2006 Nov. 4(11):865-73. Epub 2006 Oct 9. Abstract l Full Text

Haynes BF and Montefiori DC. Aiming to Induce Broadly Reactive Neutralizing Antibody Responses with HIV-1 Vaccine Candidates. Expert Review of Vaccines. 2006 Aug;5(4):579-595. Abstract l Full Text