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The Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) was funded by the National Institute of Allergy and Infectious Diseases to overcome the major immunological roadblocks in HIV vaccine design and development. More

Press Releases

A T cell and the Human Immunodeficiency Virus

Human Mode of Responding to HIV Vaccine Is Conserved from Monkeys
Duke News and Communications
January 15, 2015

New Analysis of Old HIV Vaccines Finds Potentially Protective Immune Response
Duke News and Communications
August 28, 2014

New Research from Boston and Duke Universities Offers New Hope for HIV Vaccine Development
Boston University School of Medicine
August 13, 2014

Announcements

Drs. Larry Liao and Thomas Kepler, 2014 Norman Letvin Scholars of the Duke CHAVI-ID

2014 Duke CHAVI-ID Awardees announced
October 24, 2014

Third Annual Retreat and Meeting
September 28-October 1, 2014

Sallie Permar to receive Presidential Early Career Award
December 23, 2013

Recent Publications

Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved.
Wiehe K, Easterhoff D, Luo K, Nicely NI, Bradley T, Jaeger FH, Dennison SM, Zhang R, Lloyd KE, Stolarchuk C, Parks R, Sutherland LL, Scearce RM, Morris L, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Sinangil F, Phogat S, Michael NL, Kim JH, Kelsoe G, Montefiori DC, Tomaras GD, Bonsignori M, Santra S, Kepler TB, Alam SM, Moody MA, Liao HX, Haynes BF. Immunity. 2014 Dec 18;41(6):909-18.

Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.
Xu H, Schmidt AG, O'donnell T, Therkelsen MD, Kepler TB, Moody MA, Haynes BF, Liao H, Harrison SC, Shaw DE. Proteins. 2014 Dec 18. [Epub ahead of print]

Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.
Asmal M, Luedemann C, Lavine CL, Mach LV, Balachandran H, Brinkley C, Denny TN, Lewis MG, Anderson H, Pal R, Sok D, Le K, Pauthner M, Hahn BH, Shaw GM, Seaman MS, Letvin NL, Burton DR, Sodroski JG, Haynes BF, Santra S. Virology. 2014 Nov 22;475C:37-45.

Video Presentations


Broadly neutralizing HIV-1 antibody identified in a lupus patient
March 11, 2014
Dr. Barton Haynes, Duke CHAVI-ID Director, discusses recent findings from a study led by Duke CHAVI-ID investigators in which a broadly neutralizing antibody was identified in a lupus patient who was chronically infected with HIV.