The Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) was funded by the National Institute of Allergy and Infectious Diseases to overcome the major immunological roadblocks in HIV vaccine design and development. More

Press Releases

A T cell and the Human Immunodeficiency Virus

New Analysis of Old HIV Vaccines Finds Potentially Protective Immune Response
Duke News and Communications
August 28, 2014

New Research from Boston and Duke Universities Offers New Hope for HIV Vaccine Development
Boston University School of Medicine
August 13, 2014

Gut Flora Influences HIV Immune Response
Duke News and Communications
August 13, 2014


Drs. Larry Liao and Thomas Kepler, 2014 Norman Letvin Scholars of the Duke CHAVI-ID

2014 Duke CHAVI-ID Awardees announced
October 24, 2014

Third Annual Retreat and Meeting
September 28-October 1, 2014

Sallie Permar to receive Presidential Early Career Award
December 23, 2013

Bart Haynes presents on the pathways of affinity maturation of HIV-1 broadly neutralizing antibodies
AIDS Vaccine 2013
October 31, 2013

Recent Publications

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD.‚Äč Nature. 2014 Oct 8. doi: 10.1038/nature13808. [Epub ahead of print]

Aggregate complexes of HIV-1 induced by multimeric antibodies.
Stieh DJ, King DF, Klein K, Liu P, Shen X, Hwang K, Ferrari G, Montefiori DC, Haynes B, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Robb ML, Kim JH, Denny TN, Tomaras GD, Shattock RJ. Retrovirology. 2014 Oct 2;11(1):78. [Epub ahead of print]

Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies.
Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF. Cell Host Microbe. 2014 Sep 10;16(3):304-313. doi: 10.1016/j.chom.2014.08.006.

Video Presentations

Broadly neutralizing HIV-1 antibody identified in a lupus patient
March 11, 2014
Dr. Barton Haynes, Duke CHAVI-ID Director, discusses recent findings from a study led by Duke CHAVI-ID investigators in which a broadly neutralizing antibody was identified in a lupus patient who was chronically infected with HIV.