The Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) was funded by the National Institute of Allergy and Infectious Diseases to overcome the major immunological roadblocks in HIV vaccine design and development. More

Press Releases

A T cell and the Human Immunodeficiency Virus

Powerful HIV Antibodies May Require Assist from Second Antibody to Develop
National Institute of Allergy and Infectious Diseases
July 25, 2014

Mechanism Found for the Development of Protective HIV Antibodies
Duke News and Communications
July 24, 2014

Unique individual demonstrates desired immune response to HIV virus
March 10, 2014
Duke News and Communications

Recent Publications

Cooperation of B Cell Lineages in Induction of HIV-1 Broadly Neutralizing Antibodies.
Feng Gao, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, Kwan-Ki Hwang, Hongshuo Song, Tongqing Zhou, Rebecca M. Lynch, S. Munir Alam, M. Anthony Moody, Guido Ferrari, Mark Berrong, Garnett Kelsoe, George M. Shaw, Beatrice H. Hahn, David C. Montefiori, Gift Kamanga, Myron Cohen, Peter Hraber, Peter D. Kwong, Bette T. Korber, John R. Mascola, Thomas B. Kepler and Barton F. Haynes. Cell. 2014 Jul 24. [Epub ahead of print]

Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8+ T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus.
Song H, Hora B, Bhattacharya T, Goonetilleke N, Liu MK, Wiehe K, Li H, Iyer SS, McMichael AJ, Perelson AS, Gao F. PLoS One. 2014 Jul 16;9(7):e102734. doi: 10.1371/journal.pone.0102734. eCollection 2014.

Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Fera D, Schmidt AG, Haynes BF, Gao F, Liao HX, Kepler TB, Harrison SC. Proc Natl Acad Sci U S A. 2014 Jun 30. pii: 201409954. [Epub ahead of print]

Video Presentations

Broadly neutralizing HIV-1 antibody identified in a lupus patient
March 11, 2014
Dr. Barton Haynes, Duke CHAVI-ID Director, discusses recent findings from a study led by Duke CHAVI-ID investigators in which a broadly neutralizing antibody was identified in a lupus patient who was chronically infected with HIV.