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The Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) was funded by the National Institute of Allergy and Infectious Diseases to overcome the major immunological roadblocks in HIV vaccine design and development. More

Press Releases

A T cell and the Human Immunodeficiency Virus

Diversion of an HIV Vaccine Immune Response by Antibodies Reactive with Gut Microbiome
Duke News and Communications
July 30, 2015

Antibody Response Linked To Lower Mother-to-Child HIV Transmission
Duke News and Communications
June 9, 2015

Human Mode of Responding to HIV Vaccine Is Conserved from Monkeys
Duke News and Communications
January 15, 2015

Announcements

Drs. Larry Liao and Thomas Kepler, 2014 Norman Letvin Scholars of the Duke CHAVI-ID

2014 Duke CHAVI-ID Awardees announced
October 24, 2014

Third Annual Retreat and Meeting
September 28-October 1, 2014

Sallie Permar to receive Presidential Early Career Award
December 23, 2013

Recent Publications

Diversion of HIV-1 vaccine–induced immunity by gp41-microbiota cross-reactive antibodies
Wilton B. Williams, Hua-Xin Liao, M. Anthony Moody, Thomas B. Kepler, S. Munir Alam, Feng Gao, Kevin Wiehe, Ashley M. Trama, Kathryn Jones, Ruijun Zhang, Hongshuo Song, Dawn J. Marshall, John F. Whitesides, Kaitlin Sawatzki, Axin Hua, Pinghuang Liu, Matthew Z. Tay, Kelly Seaton, Xiaoying Shen, Andrew Foulger, Krissey E. Lloyd, Robert Parks, Justin Pollara, Guido Ferrari, Jae-Sung Yu, Nathan Vandergrift, David C. Montefiori, Magdalena E. Sobieszczyk, Scott Hammer, Shelly Karuna, Peter Gilbert, Doug Grove, Nicole Grunenberg, Julie McElrath, John R. Mascola, Richard A. Koup, Lawrence Corey, Gary J. Nabel, Cecilia Morgan, Gavin Churchyard, Janine Maenza, Michael Keefer, Barney S. Graham, Lindsey R. Baden, Georgia D. Tomaras, and Barton F. Haynes Science aab1253Published online 30 July 2015 [DOI:10.1126/science.aab1253]

Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission
Gombos RB, Kolodkin-Gal D, Eslamizar L, Owuor JO, Mazzola E, Gonzalez AM, Korioth-Schmitz B, Gelman RS, Montefiori DC, Haynes BF, Schmitz JE. Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission. J Virol. 2015 Aug 1;89(15):7813-28. doi: 10.1128/JVI.00783-15. Epub 2015 May 20. PMID: 25995259

Rhesus immune responses to SIV Gag expressed by recombinant BCG vectors are independent from pre-existing mycobacterial immunity
Korioth-Schmitz B, Perley CC, Sixsmith JD, Click EM, Letvin NL, Frothingham R. Rhesus immune responses to SIV Gag expressed by recombinant BCG vectors are independent from pre-existing mycobacterial immunity. Vaccine. 2015 Jul 17. pii: S0264-410X(15)00944-5. doi: 10.1016/j.vaccine.2015.07.010. [Epub ahead of print] PMID: 26192357

Video Presentations


Broadly neutralizing HIV-1 antibody identified in a lupus patient
March 11, 2014
Dr. Barton Haynes, Duke CHAVI-ID Director, discusses recent findings from a study led by Duke CHAVI-ID investigators in which a broadly neutralizing antibody was identified in a lupus patient who was chronically infected with HIV.