The Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) was funded by the National Institute of Allergy and Infectious Diseases to overcome the major immunological roadblocks in HIV vaccine design and development. More

Press Releases

A T cell and the Human Immunodeficiency Virus

New Analysis of Old HIV Vaccines Finds Potentially Protective Immune Response
Duke News and Communications
August 28, 2014

New Research from Boston and Duke Universities Offers New Hope for HIV Vaccine Development
Boston University School of Medicine
August 13, 2014

Gut Flora Influences HIV Immune Response
Duke News and Communications
August 13, 2014

Recent Publications

Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies.
Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF. Cell Host Microbe. 2014 Sep 10;16(3):304-313. doi: 10.1016/j.chom.2014.08.006.

Editor's Choice: Infant HIV-1 gp120 vaccination elicits robust and durable anti-V1V2 IgG responses and only rare Envelope-specific IgA responses.
Genevieve G. Fouda, Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Petronella Muresan, Justin Pollara, Lin Ye Song, Brooke E. Liebl, Kaylan Whitaker, Xiaoying Shen, Nathan A. Vandergrift, R. Glenn Overman, Nicole L. Yates, M. Anthony Moody, Carrie Fry, Jerome H. Kim, Nelson L. Michael, Merlin Robb, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Hua-Xin Liao, Barton F. Haynes, David C. Montefiori, Guido Ferrari, Georgia D. Tomaras, and Sallie R. Permar. J Infect Dis. First published online August 27, 2014 doi:10.1093/infdis/jiu444

HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria.
Trama AM, Moody MA, Alam SM, Jaeger FH, Lockwood B, Parks R, Lloyd KE, Stolarchuk C, Scearce R, Foulger A, Marshall DJ, Whitesides JF, Jeffries TL Jr, Wiehe K, Morris L, Lambson B, Soderberg K, Hwang KK, Tomaras GD, Vandergrift N, Jackson KJ, Roskin KM, Boyd SD, Kepler TB, Liao HX,Haynes BF. Cell Host Microbe. 2014 Aug 13;16(2):215-226. doi: 10.1016/j.chom.2014.07.003.

Video Presentations

Broadly neutralizing HIV-1 antibody identified in a lupus patient
March 11, 2014
Dr. Barton Haynes, Duke CHAVI-ID Director, discusses recent findings from a study led by Duke CHAVI-ID investigators in which a broadly neutralizing antibody was identified in a lupus patient who was chronically infected with HIV.